What has been going on in the life sciences world this week? Find out in this week’s edition of Week in Brief.
A clinical trial of an injectable immunotherapy for head and neck cancer has shown promising results, with treatment leading to tumour shrinkage in over 40% of patients. The approach blocks cancer drivers, stimulates the immune system and could improve outcomes for patients with difficult-to-treat disease.
A new study has shown that a rare subtype of childhood leukaemia can originate during fetal development, years before symptoms emerge. By tracing the genetic history of cancer cells using neonatal blood spots, researchers have gained new insight into the earliest stages of disease formation and progression.
Scientists have generated one of the most comprehensive genomic datasets for breast cancer in Native American populations to date. The research highlights genetic features that have been underrepresented in previous studies and could help improve the equity and accuracy of precision medicine approaches.
Researchers have uncovered evidence that biological changes linked to Alzheimer’s disease may begin many years before clinical symptoms appear. The findings could support earlier detection strategies and help identify individuals who may benefit from preventive interventions.
Scientists have developed an RNA-based therapy that targets a genetic cause of heart failure by altering how a disease-associated gene is processed. In preclinical studies, the treatment improved cardiac function, demonstrating the potential of RNA medicines for inherited cardiovascular disorders.
A large genetic study has found that postpartum psychosis has a substantial inherited component, identifying genetic factors associated with increased risk. The findings improve understanding of the biological basis of the condition and may support future efforts to develop predictive tools and targeted treatments.
Researchers have developed a genomic test that could help identify breast cancer patients who are unlikely to benefit from chemotherapy and may be treated effectively with hormone therapy alone. The approach has the potential to reduce unnecessary treatment and spare patients from avoidable side effects while maintaining clinical outcomes.
A study of the human eye has identified genetic factors that influence key aspects of its structure and development. The findings provide new insight into the biological mechanisms underlying vision and could help researchers better understand diseases that affect eyesight.
In the wake of the current Ebola outbreak in the Democratic Republic of Congo, scientists are working on a vaccine using technology developed during the COVID-19 pandemic. It is thought the vaccine could be ready for clinical trials within two to three months.
Scientists have developed a wearable ultrasound patch to continuously monitor babies in the womb, offering a new approach to tracking fetal health during pregnancy. The device can measure blood flow and fetal activity in real time over extended periods, potentially enabling earlier detection of complications such as growth restriction and pre-eclampsia.
Check out last week’s Week in Brief here.
