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Genomics week in brief: Week ending 24th June

Check out the latest Genomics Week In Brief – full of intriguing news and research from the genomics space!

Top stories from the past week:

  • Researchers have created a model of GATA2 deficiency, identifying disease-associated mutations and mechanisms. The findings could subsequently lead to new treatments for the debilitating blood disorder (Cell Reports).
  • Most women carrying mutations linked to early menopause didn’t actually suffer from the condition, according to a new study. This calls previous work into question and suggest that early menopause is caused by a number of different factors (Nature Medicine).
  • Researchers have developed a tool called ‘Multiplex Genome Architecture Mapping’ that allows for better analysis of chromatin contacts on a genome-wide scale (Nature Methods).
  • A transcriptomic study of individuals who have spent time on the International Space Station revealed changes in leukocyte gene expression linked to space travel (Frontiers in Immunology).
  • Alzheimer’s disease may start to develop during embryogenesis, according to a recent study (Stem Cell Reports).
  • Scientists have described the structure of a DNA repair complex that is crucial in protecting against cancer (Nature).
  • Early reports suggest that CAR-T cell therapy could be modified to treat an autoimmune disorder (The Lancet Neurology).
  • Scientists have developed a gene therapy technique that could treat a serious developmental epilepsy syndrome (Journal of Clinical Investigation).
  • Variants linked to high LDL-cholesterol levels are also associated with coronary heart disease risk, according to a recent study (Circulation).
  • Loss of the Y chromosome allows cancer cells to evade the immune system in some male cancers (Nature).
  • Researchers have identified a tissue type, and related genes, in certain ovarian cancers that is linked to better prognosis (Cell Reports Medicine).
  • The protein GCN1 has been seen to play a vital role in the targeted degradation of erroneous proteins (Cell).
  • Scientists have developed ‘universal donor stem cells’ that could one day be used to treat degenerative brain disorders (Advanced Science).

In other news:

  • A new gene therapy for Duchenne Muscular Dystrophy has been approved by the US Food and Drug Administration (Nationwide Children’s).
  • A study has suggested that the global number of diabetes patients will increase to 1.3 billion by 2050 (The Lancet).
  • Finally, experts have warned that dangerous mosquito-borne diseases – such as Dengue fever and Zika virus – are becoming more prevalent in Europe (BBC).