Spatial context matters in complex biology. From cancer prevention to cancer biology, and for both translational and clinical studies, multiomic spatial biology is proving to be an exceptional tool to answer new questions and accelerate results.
In this webinar, the winner- of the Spatial Biology EACR & NanoString Grant program, in collaboration with Illumina, will present their cancer research study as they unravel biological complexity in the immune landscape in brain metastasis using spatial technologies.
In situ spatial transcriptomics, powered by GeoMx™ Digital Spatial Profiler, allows you to decide where to draw the line in choosing the tissue microenvironments and cell types that matter most for your research projects. Allowing the tissue sample to be the guide means it is possible to gather accurate information about spatial relationships among populations of cells, and ultimately uncover novel and effective clinical treatments.
Are you in search of innovative biomarkers, new drug targets, or distinctive gene and protein signatures?
Join this webinar to:
- Gain perspective on the heterogeneity of immune response and understand how it is impacted by the tumour microenvironment.
- Obtain new ideas, approaches and lessons learned relating to whole transcriptome spatial analysis as well as spatial multiomics work from recent publications.
- Learn from you peers how you can get a complete picture of biology at any scale, with multi-analyte profiling, highest plex and spatial context.
- Discover how you could uncover the next Immuno-Oncology biomarker with the new +570 protein GeoMx® IO Proteome Atlas (IPA)
NanoString spatial biology solutions – Discover where biology happens
Speaker: Rudy Van Eijsden, NanoString Technologies
Speaker: Vivek Kumar Mishra, Illumina
Case study: Exploring the spatial context of tumour microenvironment evolution upon radiotherapy and adenosine blockade in brain metastasis
Speaker: Anna Salamero Boix, Graduate Student, Georg-Speyer Haus, Frankfurt
Abstract: Brainmetastasis is an unmet clinical need in high demand for novel and effective treatments. In preclinical brain metastasis models, we found that combining radiotherapy with adenosine blockade leads to better tumour control. We leveraged the GeoMx® DSP platform to spatially characterize the cellular and molecular dynamics of the murine brain metastasis tumour microenvironment upon radiotherapy and adenosine blockade. We observed treatment-specific alterations in the immune landscape and identified underlying pathways associated with anti-cancer immunity.
Q & A with speakers.