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Mitochondrial DNA genotype-phenotype interactions

A recent study has found that genetic variants in mitochondrial DNA could increase the risk of developing several common diseases, […]

Phenotype prediction accuracy limited by negative selection

Using population genetic models, researchers show that negative selection on complex traits limits phenotype prediction accuracy between populations. Phenotype prediction […]

Mitochondrial stress: a phenotype of spaceflight

Spaceflight is known to impact human physiology, but the distinct molecular aetiologies are unknown. In a recent study, published in […]

Pheno-RNA: a method to associate genes with phenotypes

In a recent article, published in PNAS, researchers have described a new method – Pheno-RNA – to identify candidate genes […]

Human brain-derived proteome data helps elucidate a genetic causal pathway for neurological phenotypes

A team of researchers have analysed human proteome data from brain tissue to study whether targeted proteins predictively mediated the […]

Genomics Week in Brief: Week ending 23rd September

Welcome to the latest Week in Brief, where we provide a summary of cutting-edge research from the last seven days! […]

The State Of: Genomics in Mental Health Research

The advent of genetic and genomics research has transformed our understanding of thousands of human diseases, with our abilities ever […]

Largest study of its kind reveals risk genes for epilepsy development

Over 50 million people worldwide are currently living with epilepsy. However, one third of patients are resistant to common antiseizure […]

AI can accurately detect Parkinson’s disease and define its subtypes

Parkinson’s disease is a clinically heterogenous neurodegenerative disorder, meaning that it is likely that different cellular mechanisms drive its pathology […]

Rebalancing immune hyperactivity in Down’s syndrome

Written by Charlotte Harrison, Science Writer  People with Down’s syndrome have chronic hyperactivation of interferon signalling, meaning they are at […]