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Patient Perspectives: Sarah Winckless – Leadership and Performance Coach and Olympic Bronze Medallist

Sarah Winckless is a former British rower, Bronze Olympic Medallist and the first woman to umpire the men’s Boat Race. […]

A high mutational burden is not fully responsible for ageing

Despite previous thoughts, researchers have now found that cells tolerate a lot more mutations without impacting their function. Mutational burden […]

A longstanding mystery: How do identical twins arise?

Scientists have discovered DNA methylation differences that are unique to identical twins, helping to unravel the exact molecular events that […]

Why is understanding cancer evolution so important?

In 1976, Peter Nowell first formally described cancer as an evolutionary process. This was the beginning of the notion that […]

The Cancer Gene Directory

BRCA1 gene Name: BReast CAncer gene 1 Type of gene: Tumour suppressor gene responsible for repairing DNA located on chromosome […]

Cancer Genomics: From Diagnosis to Treatment

Introduction The first publication of cancer genome sequencing was in 2006, whereby more than 13,000 genes involved in breast and […]

Epigenome-wide analysis to identify coronary heart disease therapeutic targets

A group of international researchers has performed the first prospective epigenome-wide analysis of DNA methylation in relation to incident CHD […]

Longevity pathways identified in exome analysis of centenarians

Non-human model organisms have provided evidence to suggest that rare protein-coding variants in pathways linked to longevity can guard against […]

Regulating human germline genome editing

Researchers have recently published a paper describing how the development of an ‘informed adaptive consensus’ approach to regulating human germline […]

Schizophrenia polygenic risk scores: The struggle of improving their clinical utility

Researchers have analysed clinical and genetic data from over 8,500 adults with psychiatric disorders, to assess whether schizophrenia polygenic risk […]