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Modified guide RNAs boost CRISPR-Cas13 transcript knockdown

Researchers at New York University and the New York Genome Center have developed chemically modified guide RNAs that enhance CRISPR-Cas13 […]

Genome Giants – Janet Thornton – Senior Scientist and Director Emeritus at EBI

Dame Janet Thornton is a Senior Scientist and Emeritus Director of EMBL-EBI. Thornton is a pioneer in structural bioinformatics, having […]

A, C, T to Glossary

Numbers The 1000 Genomes Project: The 1,000 Genome Project (1KGP) launched in January 2008 with the aim of generating the […]

Pan-cancer tumour organoids pave the way towards precision medicine

Researchers have developed a platform of pan-cancer tumour organoids and a neural-network-based drug assay, that has the potential to advance […]

Reversing diabetes with a selective microRNA inhibitor

Researchers have designed a structure-specific microRNA inhibitor that selectively represses a microRNA family member, which may in turn reverse the […]

How to do RNA sequencing

RNA sequencing is an NGS technique that enables investigation of the transcriptome – the total cellular content of RNAs, including […]

Top single cell isolation techniques

Typically, conventional cell-based research focusses on the average response from a population of cells, without taking into account individual cell […]

Sample Preparation for NGS – A Comprehensive Guide

Introduction Sample preparation is the process of getting DNA ready for Next Generation Sequencing (NGS). This requires a few steps… […]

Major depressive disorder and energy metabolism: diving deep with omics technology

Omics technologies have revealed molecular insights into the complex relationship between impaired energy metabolism and major depressive disorder. Major Depressive […]

Blood stem cells are linked to the progression of aggressive brain tumours

Using transcriptome analysis and gene expression sequencing, researchers have discovered that blood stem cells (HSPCs) cause increased cell division in […]