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RNA modifications provide new insights into disease brain states

Recently, researchers have used advanced microscopy to investigate the role that RNA modifications play in ‘synaptic tagging’ within the brain. […]

Can we be genetically predisposed to psychiatric disease and addiction?

A recent study, published in NeuroResource, has used single-nucleus transcriptome analysis to identify cell-type-specific molecular signatures in the brain that […]

Evolution of cloning: A Dolly good show!

My first real memories of cloning came from a film by one of my favourite childhood bands S Club 7. […]

Choose the right single-cell multi-omics protocol

Single-cell analysis enables deeper characterization of cell populations compared to bulk sequencing, with new experimental methods continuously being developed and […]

Inhibition of protein reverses hallmark of motor neurone disease

A new study, led by scientists at UCL and the Francis Crick Institute, has found that the inhibition of an […]

Down the Rabbit Hole: Cloning and all things Dolly the Sheep – Bill Ritchie

Bill Ritchie is a retired embryologist who carried out the cloning procedure that led to the creation of Dolly the […]

A, C, T to Glossary

Numbers The 1000 Genomes Project: The 1,000 Genome Project (1KGP) launched in January 2008 with the aim of generating the […]

What are the different types of nucleic acid extraction?

Nucleic acid extraction is the first step in the NGS sample prep protocol. Nucleic acids are large biomolecules that are […]

Sample Preparation for NGS – A Comprehensive Guide

Introduction Sample preparation is the process of getting DNA ready for Next Generation Sequencing (NGS). This requires a few steps… […]

How to: generate mouse-human chimeric embryos

A recent article published in Nature Protocols has detailed a breakthrough approach in generating mouse-human chimeric embryos with human pluripotent […]