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Single-cell analysis reveals lung cancer therapy transcriptional changes

A study reported in Cell has shown through single-cell analysis that targeted lung cancer therapies result in transcriptional changes that […]

TISCH: a tumour microenvironment single-cell transcriptomic database

Researchers at Tongji University, Shanghai, have developed a large-scale curated database that integrates tumour microenvironment (TME) single-cell transcriptomic data, known […]

Susceptibility of the human embryo to SARS-CoV-2

Researchers at the University of Cambridge and the California Institute of Technology (Caltech) have identified genes active in early embryonic […]

Digestive tract organs: a pathogenic route for SARS-CoV-2 infection

A recent article published in Cell Death Discovery has explored digestive symptoms of COVID-19 and the potentially pathogenic route of […]

Variants in ACE2 and TMPRSS2 may explain genetic susceptibility towards COVID-19

The current COVID-19 pandemic has revealed that increased age and the presence of co-existing health conditions, such as cancer, cardiovascular, […]

Biologically-validated AI is how scientists are realising the full potential of single-cell RNA sequencing

The promise of single-cell gene expression data Genomic data are an excellent source of novel disease biomarkers and targets. In […]

Study finds chemokine receptor inhibition can overcome immune hyperactivation in COVID-19 patients

A new single-cell analysis study of airway samples of COVID-19 patients has found that drugs targeting chemokine receptors may be […]

Eleven challenges in single-cell data science

Introduction: Single-cell sequencing technology has been advanced by the falling sequencing costs, a boom in microfluidics and combinatorial indexing strategies. […]

How to: Choose the best RNA sequencing method for quantitative miRNA profiling

This article has been based upon this blog post, written by Dr Karolina Szczesna. RNA sequencing (RNA-seq) uses next generation […]

RNA modification – a viral hideout

Scientists show how human metapneumonia (hMPV) virus exploits RNA modification to prevent host differentiation of self and non-self RNA, thereby […]