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Genomics week in brief: Week ending 9th January

Another week, another genomics week in brief – filled with the latest news and research from the genomics space.

Top stories from the past week

  • Using transcriptomic data, researchers have provided a detailed landscape of gene expression alterations in the temporal and frontal lobes – areas affected during early and late stages of Alzheimer’s disease pathology. (Costa et al, 2021)
  • Researchers have performed single-cell analysis of the human decidual immune microenvironment to gain insights into individuals with recurrent pregnancy loss. (Qu et al, 2021)
  • New research has discovered a new mechanism in which prostate cancer cells can ‘switch’ character and become resistant to therapy. (Selth et al, 2021)
  • A GWAS has identified novel genetic markers associated with paediatric bone accrual. (Grant et al, 2021)
  • Single-cell analysis has identified a prognostic gene signature for metastatic gastric cancer. (Wang et al, 2021)
  • New research has found that a microbe in the colon and commonly associated with the development of colitis and colon cancer, may also play a role in the development of some breast cancers. (Sharma et al, 2021)
  • Researchers have shown that glycylation is essential to keep sperm cells swimming in a straight line. These findings infer that a perturbation of this modification may underlie some forms of male infertility. (Gadadhar et al, 2021)
  • An ancient DNA analysis has revealed Asian migration and dynamics of Yersinia pestis. (Götherström et al, 2021)
  • A recent study has generated reference genomes of platypus and echidna, providing insights into mammalian biology and evolution. (Zhang et al, 2021)
  • Researchers from Tokyo Medical and Dental University have discovered two novel genetic variants in a protein made by antibody-forming immune cells, providing a mechanism for the development of Guillain-Barré syndrome. (Tsubata et al, 2021)
  • A team has shown that gene therapy of the tumour suppressor gene – TSC2 – can effectively treat a mouse model for tuberous sclerosis complex. (Cheah et al, 2021)

In other news

  • The NHGRI has released a new action agenda for a diverse genomics workforce. (NHGRI, 2021)
  • Researchers at the National Institute of Standards and Technology (NIST) have compiled the first detailed tutorial on DNA origami. (Majikes and Liddle, 2021)


  • Join us for our annual Festival of Genomics & Biodata. The Festival is the UK’s largest Genomics event. This year we’re expecting over 5,000 attendees from across the globe. It is taking place between 26-29th January – so register now.
  • Join us for our brand-new three-part webinar series – ‘Multi-Omics ONLINE’ . We will be bringing together global experts who are harnessing diverse datasets to advance our understanding of human health and disease. Register now.

More on these topics

Genomics / Single cell / Week in brief