Another week, another genomics week in brief – filled with the latest news and research from the genomics space.
Top stories from the past week
- Using transcriptomic data, researchers have provided a detailed landscape of gene expression alterations in the temporal and frontal lobes – areas affected during early and late stages of Alzheimer’s disease pathology. (Costa et al, 2021)
- Researchers have performed single-cell analysis of the human decidual immune microenvironment to gain insights into individuals with recurrent pregnancy loss. (Qu et al, 2021)
- New research has discovered a new mechanism in which prostate cancer cells can ‘switch’ character and become resistant to therapy. (Selth et al, 2021)
- A GWAS has identified novel genetic markers associated with paediatric bone accrual. (Grant et al, 2021)
- Single-cell analysis has identified a prognostic gene signature for metastatic gastric cancer. (Wang et al, 2021)
- New research has found that a microbe in the colon and commonly associated with the development of colitis and colon cancer, may also play a role in the development of some breast cancers. (Sharma et al, 2021)
- Researchers have shown that glycylation is essential to keep sperm cells swimming in a straight line. These findings infer that a perturbation of this modification may underlie some forms of male infertility. (Gadadhar et al, 2021)
- An ancient DNA analysis has revealed Asian migration and dynamics of Yersinia pestis. (Götherström et al, 2021)
- A recent study has generated reference genomes of platypus and echidna, providing insights into mammalian biology and evolution. (Zhang et al, 2021)
- Researchers from Tokyo Medical and Dental University have discovered two novel genetic variants in a protein made by antibody-forming immune cells, providing a mechanism for the development of Guillain-Barré syndrome. (Tsubata et al, 2021)
- A team has shown that gene therapy of the tumour suppressor gene – TSC2 – can effectively treat a mouse model for tuberous sclerosis complex. (Cheah et al, 2021)
In other news
- The NHGRI has released a new action agenda for a diverse genomics workforce. (NHGRI, 2021)
- Researchers at the National Institute of Standards and Technology (NIST) have compiled the first detailed tutorial on DNA origami. (Majikes and Liddle, 2021)
Events
- Join us for our annual Festival of Genomics & Biodata. The Festival is the UK’s largest Genomics event. This year we’re expecting over 5,000 attendees from across the globe. It is taking place between 26-29th January – so register now.
- Join us for our brand-new three-part webinar series – ‘Multi-Omics ONLINE’ . We will be bringing together global experts who are harnessing diverse datasets to advance our understanding of human health and disease. Register now.
