Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!
Top stories from the past week:
- Multi-omics study reveals new insights into the genomic landscape of acute lymphoblastic leukaemia (Nature)
- First U.S patient receives autologous stem cell therapy to treat dry age-related macular degeneration (ClinicalTrials.gov)
- Research develop new innovative type of CAR T-cell and demonstrate the high safety and efficacy of this non-viral, gene-specific integrated CAR-T cell for cancer therapy (Nature)
- Study demonstrates the ability of synthetic embryos outside the body to reconstitute mammalian development through and beyond gastrulation to neurulation and early organogenesis (Nature)
- Single-cell analysis reveals dysregulated naïve B cells lead to autoreactivity in severe COVID-19 (Nature)
- Researchers develop “helixCAM” a platform to engineer synthetic cell adhesion molecules to program cell assembly in bacteria and human cells (Cell)
- A new deep mutational learning model can accurately predict the impact of mutations on the ACE2 receptor-binding domain in SARS-CoV-2 (Cell)
- Researchers computationally design membrane-permeable and orally bioavailable peptides (Cell)
- New multi-omics study elucidates molecular heterogeneity of KMT2A-rearranged leukaemia (Nature)
- Genomic surveillance study shows that COVID-19 has diverse circulating lineages in Kenya (BMC Genomics)
- New study uses RNA-seq to reveal pathogenic variants in Cornelia de Lange syndrome (Genomics)
- New machine-learning tool coverts single-cell data and tumour transcriptomes into signals to classify cancer origin of undiagnosable cancers (Cancer Discovery)
- Single-cell RNA-seq study uncovers how cancer-associated fibroblasts participate in T-cell exclusion, which impacts the efficacy of T-cell therapies (Cancer Discovery)
In other news:
- Study suggests that new Omicron -specific vaccines offer similar protection to existing boosters (Nature)
- Data shows that nearly half of all cancer deaths are preventable, caused by smoking, alcohol consumption, etc. (Scientific American)
- Pilot study suggests the hormone GnRH may be a new potential therapeutic target for Down Syndrome (Scientific American)
