Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!
Top stories from the past week:
- Researchers discover mechanism by which air pollution triggers lung cancer in non-smokers (Nature)
- Computational algorithm combats formalin-induced artefacts in mutational signatures (Nature)
- Whole-genome assemblies of cnidarians reveals the mechanisms behind rejuvenation, challenging current understanding of aging (PNAS)
- Three-pronged approach could improve antigen prediction for immune-based therapies. Approach incorporates quantification of the geometry of the antigen landscape, coupling of antigen recognition to other cellular responses, and diversifying training sets (Journal of Experimental Medicine)
- Functional genomics analysis reveals BNC2 is a transcription factor involved in driving myofibroblast activation, and could prove to be a druggable target for future research (Nature Communications)
- Long non-coding RNA signature found to improve prognosis predication and immunotherapy response in lung adenocarcinoma patients (Frontiers in Genetics)
- GWAS reveal that circulating metabolites and biochemical traits may play causal role in psychiatric disorders, mediated by changes in the cerebral cortex (Nature)
- Single-cell analysis shows how normal cells transition to tumour state with help from the surrounding microenvironment (Nature Genetics)
- Cistrome-wide association study framework could help identify genetic determinants of chromatin that mediate prostate cancer risk (Nature Genetics)
- Single-molecule epigenetic analysis of plasma-isolated nucleosomes provides potentially vital information of clinical relevance to cancer diagnostics (Nature Biotechnology)
- GWAS identifies 99 gene loci linked to physical activity levels that could provide an insight into how sedentary behaviour influences disease risk (Nature Genetics)
In other news:
- Genomics analysis uncovers the gruesome truth behind an ancient mass burial site; human remains linked to those of a group of medieval Jews killed in an antisemitic massacre (Nature News)
- Domestication history of donkeys uncovered thanks to genomic analysis (Science)
- New research reveals the role of the gut-microbiome connection in driving cravings for fatty foods, suggesting a possible avenue for further research to reduce overeating (Nature)
- The National Human Genome Research Institute has announced $3.35 million in funding over the next five years to promote diversity in genomics training (NIH)
