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Genomics week in brief: Week ending 3rd June

Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!

Top stories from the past week

  • German researchers present a new gene correction approach providing improved safety and suitability for gene therapy. (Tran et al)
  • A recent study has demonstrated that a protein therapy for neovascular age-related macular degeneration is safe in humans and can outperform standard treatments in mice and nonhuman primates. (Yang et al)
  • Researchers have found a genetic mutation that strengthens the tendons in mice which may boost human athletic performance. (Nakamichi et al)
  • New findings suggest that image analysis can be used to predict clinical end points in patients receiving immune checkpoint inhibitors. (Wang et al)
  • A new cell study reveals how mutations confer treatment resistance in cancerous B cells. (Dhami et al)
  • Researchers from Wuhan and California present a machine-learning method based on gradient boosting, to identify genome-wide cis-regulatory elements and their relationship to target genes. (Zhang et al)
  • New research indicates that type 2 innate lymphoid cells can have immunosuppressive effects in colorectal cancer. (Jou et al)
  • A team of researchers found the RNA exosome is required for early B cell development providing a clear and unified molecular mechanism for B cell immunodeficiency associated with THES. (Yang et al)
  • A review summarises the last 60 years of research into circadian rhythms and how they can control immunity. (Wang et al)
  • Using single-nucleosome imaging, researchers have revealed the steady-state motion of interphase chromatin in living human cells. (Iida et al)
  • A new review explores how T cells follow the law of initial value when responding to a changing environment. (Huseby and Teixeiro)
  • A pre-proof has conducted a meta-analysis looking at the long term impact of Helicobacter pylori eradication therapy on gastric cancer in healthy infected individuals over 10 years. (Ford et al)

In other news:

  • African scientists lead a biodiversity genomics revolution (Science Africa)
  • A treatment trial targeting a genetic pathway in breast cancer offers an overall survival advantage. (BBC)
  • Scientists eliminate chronic pain in mice and primates using gene therapy (In Neoscope based on Tadokoro et al)

Image credit: canva

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Cancer / Gene Editing / Genomics / Week in brief