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Genomics week in brief: Week ending 30th July

Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!

Top stories from the past week

  • Genome-wide CRISPR screen identifies factors regulating loss of pluripotency in mice embryonic stem cells (Gao et al). 
  • Using liquid biopsy to analyse circulating cell-free DNA in organ and tissue transplants (Heidrich et al). 
  • Studies on human monocytes suggest cohesin has a critical function in controlling long-term, differentiation and activation of gene expression (Minderjahn et al). 
  • Engineering a CRISPR interference system to prevent antibiotic resistance in E.Coli (Wan et al). 
  • Multi-omics study reveals eight common genetic correlations between psychiatric and neurodegenerative diseases (Wingo et al). 
  • CRISPR-Cas9 induced DNA nicks induce specific mutational signatures associated with BRCA1 deficiency (Feng et al). 
  • New method ExtRaINSIGHT allows for measurement of strong purifying selection in protein coding genes, shedding new light on the genome-wide distribution of fitness effects (Dukler et al). 
  • CDK1 identified as a hub gene involved in melanoma metastasis and potential therapeutic target (Luan et al). 
  • Famine and disease led to the development of lactose intolerance in Europe (Evershed et al). 
  • Phylogenetic studies on ancient herpes simplex 1 genomes reveal the origins of modern viral strains (Guellil et al). 
  • Analysis of patterns in covariance may help predict the continued evolution of SARS-CoV-2 as a human pathogen (Robins et al). 
  • New targeted sequencing panel ClinPharmSeq offers broad implementation of pharmacogenetic testing (Lee et al). 
  • Clinical significance of Na/K-ATPase regulation in dilated cardiomyopathy revealed in recent multi-omics study (Gao et al). 
  • Transcriptome analysis study suggests advanced glycation end products may contribute to the development of diabetic tendinopathy (Patel et al). 
  • New transgenic mouse models developed for susceptibility and resistance to SARS-CoV-2 infection (Seo et al). 
  • Rare mutation in PTPRA gene may contribute to the development of Parkinson’s Disease (Hill et al). 
  • Pharmacogenetic tests reveal that genetic variations in the lncRNA gene UCA1 determine endometriosis development and may be associated with infertility (Chang et al). 
  • Novel system optogenetic control of mitochondria-lysosome contacts provides a platform to study mitochondrial fission for the treatment of mitochondrial disease (Kangqiang et al). 

In other news:

  • South Korea’s Pathfinder Lunar Orbiter Danuri sets off for its first Moon mission (
  • DeepMind’s AlphaFold tool predicts the shape of nearly every known protein ( 
  • MIT engineers develop new ultrasound stickers that can continuously image changes in the lungs, hearts and stomach (MIT news). 
  • New ‘artificial synapse’ is 1 million times faster than synapses in the human brain, allowing for faster machine learning and training of neural networks (Scitech Daily).

Image credit: canva

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