Welcome back to Week in Brief – your number stop for the latest genomics news!
What drives tumour growth? Researchers have been busy answering this question…
Scientists have developed an algorithm that can identify cell populations responsible for aggressive tumour growth. Identifying these drivers can help predict patient outcomes and point towards better treatments (Nature Genetics).
Several mechanisms that contribute to the progression of Ewing sarcoma have been identified in a recent study. These revelations could lead to potential therapies to counteract aggressive tumour growth (EMBO Reports).
A study has been published that challenges previous assumptions that tumours grow as a ‘two-speed’ entity. The work suggests that cancers grow uniformly throughout their mass, shedding new light on tumour growth dynamics (eLife).
What about links between our genes and other health conditions?
New research suggests that a genetic predisposition to lower insulin production is a key driver behind early onset type 2 diabetes, and subsequent complications, in those of British-Asian descent (Nature Medicine).
A new method to measure gene activity in the brain has been developed. Using electrodes implanted in the brain, ‘molecular traces’ can be mapped; this information could be used to understand and treat neurological disorders (JCI Insight).
Researchers have identified a novel genetic cause of the rare but serious condition known as mitochondrial DNA depletion syndrome, using whole genome and RNA sequencing (Liver International).
There are exciting updates from the immunology field…
Researchers have identified rare genetic variants in a gene that regulates immune cells as a key factor in why some children develop Multisystem Inflammatory Syndrome in Children (MIS-C) after COVID-19. These findings may improve risk prediction and treatment approaches for similar inflammatory conditions (JEM).
A recent study has revealed a backup mechanism used to protect cells against the threat of ‘invaders’. This mechanism is employed as part of the immune response when the usual RNA editing mechanism fails (Science Immunology).
What else has gone on this week?
A single histone modification has been identified as a key player in cells’ ability to remember their identify and function. Issues with this chemical alteration can lead to cancer (Genes & Development).
Using Mendelian randomisation, researchers have discovered genetic links between depression and menstrual pain. They discovered that depression may be a cause of period pain, but that the inverse is not true (Briefings in Bioinformatics).
Check out last week’s Week in Brief here.
