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Genomics week in brief: Week ending 27th May

Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!

Top stories from the past week

  • This week, gene therapy effectively treated advanced-stage muscular dystrophy in a mouse model. (Yonekawa et al)
  • A new study of samples from patients with inherited acidemia leads to an experimental gene therapy. (Head et al)
  • Researchers have shed light on potentially bioactive gene products in inflammatory bowel diseases, offering therapeutic targets. (Zhang et al)
  • Within a special issue on the multiplicity of microbiomes, a review considers how “omics” research has expanded our knowledge of how a host’s tissues and microbiota interact. (Lu & Stappenbeck)
  • Researchers from Lanzhou University Secondary Hospital identify a potential therapeutic target for diffuse-type gastric cancer. (Qin et al)
  • A new study investigated synthetic gene circuits and how they could prevent the disruption of the circadian rhythm in cartilage. (Pferdehirt et al)
  • A team of researchers demonstrated that PACT plays a key role in regulating mitochondrial biogenesis and energetics in cell. (Dogan et al)
  • French researchers present T cell immunogenicity and gene expression profiles from the results of a HIV vaccine trial in healthy volunteers. (Richert et al)
  • A new study identified an RNA-editing enzyme as masking the cancer immunotherapeutic promise of ZBP1-driven necroptosis. (Zhang et al)
  • Scientists have defined mitochondrial protein functions through deep multiomic profiling. (Rensvold et al)
  • Through bioinformatic prospecting, researchers discovered and synthesized a novel, naturally inspired bifunctional lipopeptide antibiotic with a low resistance potential. (Seipke)
  • Using RNA sequencing, a new study has shown that transcriptional regulators can substantially alter disorder outcome, implicating them as therapeutic targets. (Burda et al)
  • A new study connects genomics and proteomics to identify protein biomarkers for adult and youth-onset type 2 diabetes. (Ghanbari et al)

In other news:

  • Pompeii victim’s genome successfully sequenced for first time (The Guardian, Science)
  • Karen Miga, who led the Telomere-to-Telemere Consortium, is named one of TIME’s 100 most influential people of 2022 (TIME, University of California)
  • Spanish researchers obtain the first 100% genome sequence draft of the monkeypox virus. (EuroWeekly)
  • More than a third of severely sick babies referred for rapid whole genome sequencing receive vital genetic diagnosis in latest study across the East of England. (Cambridge Network)

Image credit: canva

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Cancer / Gene Editing / Genomics / Week in brief