Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!
Top stories from the past week
- Rare germline deleterious variants have been found to increase susceptibility for lung cancer. (Sang et al)
- Researchers investigated DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukaemia. (Xu et al)
- University of Pennsylvania researchers demonstrated that embryo cryopreservation leads to sex-specific DNA methylation perturbations in human placentas. (Mani et al)
- Scientists demonstrated that alternative splicing plays a critical role in the formation and growth of paediatric cancers. (Venkataramany et al)
- A new study summarises the evolutionary genetic variation in type 1 diabetes and the racial and ethnic differences in type 1 diabetes epidemiology, clinical characteristics, and preclinical course. (Redondo et al)
- Researchers caution the use of cellular tests to detect Lyme Borreliosis. (Theel et al)
- A large-scale retrospective study demonstrated that the combination of serum markers and endoscopic findings was essential for the risk evaluation of gastric cancer. (Nagasaki et al)
- PDZK1 interacting protein 1 (PDZK1IP1) was identified as promoting the progression of papillary thyroid cancer. (Wang et al)
- Researchers demonstrated the use of exome sequencing as a tool for detecting point mutations and deletions in patients with hypogonadotropic hypogonadism. (Young et al)
- An international team proposed a new procedure to measure pairwise nonlinear correlations with applications for gene expression data. (Tripathi et al)
- Researchers demonstrated a high throughput SARS-CoV-2 variant analysis using molecular barcodes coupled with next generation sequencing. (Cohen-Aharonov et al)
- Single-cell analyses highlighted the proinflammatory contribution of C1q-high monocytes to Behçet’s disease. (Zheng et al)
- Researchers have discovered new molecular signatures that may help predict the long-term risk of liver cancer in patients with nonalcoholic fatty liver disease. (Fujiwara et al)
- Researchers discovered a bacterium that challenges the prevailing view of bacterial cell size – it is visible to the naked eye. (Volland et al)
In other news:
- Many researchers say they’ll share data – but don’t. (Nature)
- Experts believe a new form of photoimmunotherapy may become the fifth major cancer treatment (Guardian)
- America’s first CRISPR trials is still nearly 100% effective 3 years on. (New Atlas)
- People in Wales affected by mental health issues will be able to benefit from a new genetics service. (BBC News)
- A new technique leads to kids to having kidney transplants without immune suppression. (Science Alert)
- An MIT-led team has built a new computer model that can rapidly scan the entire genome of cancer cells and identify mutations that drive tumour growth. (MIT News)
- Drug cocktail makes stem cells that could grow organisms from scratch. (New Atlas)
Image credit: canva
