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Genomics week in brief: Week ending 24th April

We have gathered all the best and latest genomics news and research from the past week, and put it here, all in one place!

Top stories from the past week

  • Researchers have shown that rapid whole genome sequencing of newborns in intensive care units can provide timely actionable information that impacts care in infants with congenital heart disease. (Sweeney et al, 2021)
  • Mayo Clinic researchers and collaborators have found that the protein encoded by the SERPINA5 gene may worsen tau protein tangles and advance Alzheimer’s disease. (Crist et al, 2021)
  • Researchers have developed a new tool that can design much more complex DNA robots and nanodevices than ever before, in a fraction of the time. (Huang et al, 2021)
  • A new study has described a detailed analysis of the preferential degradation by autophagy of messenger RNAs. (Makino et al, 2021)
  • Beam Therapeutics’ researchers have developed and redesigned a base editor that has shown considerable promise in directly repairing the single-base change in sickle-cell disease. (Chu et al, 2021)
  • Researchers have a developed a technique – XYZeq – that enables them to simultaneously map specialised diversity and spatial locations of individual cells within a tissue or tumour. (Lee et al, 2021)
  • New findings have revealed that patients with a rare genetic condition known as 22q.11.2 deletion syndrome are at an increased risk of schizophrenia due to a leaky blood-brain barrier allowing inappropriate immune involvement. (Crockett et al, 2021)
  • Researchers have made a major breakthrough in sequencing an entire ancient bear genome from soil samples. (Pedersen et al, 2021)

In other news

  • An international research team has argued that EU legislation should be changed to allow the use of gene editing in organic farming. (Purnhagen et al, 2021)
  • A malaria vaccine becomes the first to achieve the WHO-specific 75% efficacy goal. (Datoo et al, 2021)


  • Join us tomorrow (Tuesday 27th April) at 3pm BST/4pm CEST/10am EDT for a one-off webinar focussed on “Mapping the COVID-19 T-cell response at a single-cell level.” This webinar will provide insights into COVID-19 clinical research, single-cell analysis and the measurement of T-cell response.
  • Check out the latest webinar in our ‘Cancer Genomics ONLINE’ webinar series. In this webinar, we will explore how cancer genomics impacts clinical decision making. The webinar is taking place on Thursday 29th April at 3pm BST/4pm CEST/10am EDT.
  • Join us for another webinar in the ‘COVID and Genomics ONLINE’ series on Wednesday 28th April at 3pm BST/4pm CEST/10am EDT. Here, we will be exploring how sequencing data has enabled us to identify vaccine targets for COVID-19 and the use of AI in drug discovery.

More on these topics

Genomics / Single cell / Week in brief