Mobile Menu

Genomics Week in Brief: Week ending 1st March

What’s been going on in the genomics world this week? In Week in Brief, we summarise the latest developments.

The microbiome has been further implicated in human health…

Researchers have identified different strains of bacteria in the microbiome that can predict a patient’s response to combined immunotherapy treatments (Nature Medicine).

A new study has revealed that certain inherited eye conditions could be caused by gut bacteria, due to the disease-causing mutation lowering the immune response. This finding suggests that these conditions could be treated with antimicrobials (Cell).

We’ve learned more about Alzheimer’s disease this week…

Researchers have identified a new role for the SYNGAP1 gene, which is linked to neurodevelopmental disorders. The gene has now been implicated in synaptic plasticity in mammalian brain cells (Science).

Furthermore, a study of rare mutations linked to familial Alzheimer’s disease has revealed that impaired amyloid production, not just the formation of amyloid plaques, may cause the disease (Cell Reports).

What about updates in cancer research?

Researchers have assessed the proteogenomic landscape of small cell lung cancer, in a large-scale study that could assist in the development of precision therapies (Cell).

Using AI, scientists have analysed DNA from prostate tumours and tracked genomic evolution, revealing two subtypes of the disease. This information could inform new treatment strategies (Cell Genomics).

A new genetic variant has been identified that is linked to better treatment outcomes in patients with head and neck cancers (Cancer Research Communications).

And that’s not all, check out what else went on in the last seven days…

The first analysis of ancient Eastern Arabian DNA revealed the presence of a mutation that confers resistance to malaria, that appeared after the development of agriculture in the region (Cell Genomics).

A single nuclei transcriptomics experiment has revealed mutations in the brain cells of patients with opioid-use disorder (Nature Communications).

Researchers have identified two common mutations in African American individuals that are linked to kidney failure. The work highlights the importance of diversity in genomic research and could lead to better treatment options (Journal of Clinical Investigation).

A study has revealed that tandem repeat expansions are highly linked to cardiomyopathy in children and are responsible for around 4% of cases (eBioMedicine).

Combining genetic and demographic risk factors for optic neuritis – a condition that impacts vision and is associated with later onset of multiple sclerosis – could be used to predict the risk of the latter disease and save patients’ sight (Nature Communications).

Check out last week’s Week in Brief here.