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Genomics Week in Brief: Week Ending 19th April

What’s been going on in the genomics world in the last seven days? In Week in Brief, we’ve got the answers for you!

Efforts have been made to develop non-invasive tests for various illnesses…

Scientists have discovered a biomarker that could predict acute cellular rejection after organ transplants. The biomarker could become the basis of a blood test for the condition, replacing repeated biopsies (American Journal of Transplantation).

Researchers have developed a urine test that analyses several genes linked to high-grade prostate cancer, in a bid to replace invasive tissue biopsies (JAMA Oncology).

And new strides have been made in cancer research…

A spatial experiment has identified patterns that could predict whether ovarian cancer patients will experience relapse after treatment (Science Advances).

A new study describes a computation pipeline that can predict treatment response in cancer patients at the single-cell level. The tool marks a step forward in the development of personalised treatment regimens (Nature Cancer).

A study has revealed that mutations in non-coding areas of the genome can become functional in some cancers, leading to altered gene expression and increased cell proliferation (Nature Communications).

A therapeutic target for non-small cell lung cancer has been identified, which could be targeted to prevent cancer cells evading the immune system and enhance the efficacy of immunotherapies (Immunity).

There has been news from the neuroscience and neuropsychiatry fields this week…

The largest ever genetic study of PTSD has uncovered 95 regions of the genome linked to the condition. This contributes to our understanding of why some people develop PTSD after experiencing trauma (Nature Genetics).

Scientists have discovered that accumulation of G-quadruplex DNA in neurons is responsible for expression of genes involved in memory formation (Journal of Neuroscience).

What else has been published this week?

Researchers have uncovered a complex pathway related to inflammatory bowel disease, which could shed light on the relationship between environmental triggers and immune responses (Nature Immunology).

A comprehensive cellular atlas of aging human muscle has been published. This resource highlights the processes that contribute to muscle deterioration overtime, and potential methods to overcome this (Nature Aging).

Researchers have investigated the cause of type 1 diabetes in two siblings with a seemingly unique mutation in the PD-L1 gene. The findings provide new understanding of how the condition develops (Journal of Experimental Medicine).

Finally, a large-scale study using electronic health records has identified hundreds of new genetic variants linked to tobacco use disorder. The researchers also identified potential drug targets for the condition (Nature Human Behaviour).

Check out last week’s Week in Brief here.