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Genomics week in brief: Week ending 17th September

Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!

Top stories from the past week:

  • New genomics profiling method elucidates lipid metabolism mechanism driving Zika virus infections and could be a target for therapeutic intervention (Nature Communications)
  • Study findings suggest neoadjuvant endocrine therapy alone may not be appropriate for advanced breast cancers in Black women (EurekAlert)
  • First experimental evidence shows why COVID-19 produces variants so quickly (Nature)
  • Combination of scRNA-seq and bulk-seq data identifies M2 macrophage-associated signature for prognosis prediction in lung adenocarcinoma (Frontiers in Genetics)
  • Review assesses the genetics of bipolar disorder co-occurring with obesity and type 2 diabetes (Journal of Affective Disorders)
  • Computational workflow determines extent of germiline genetic variation in ancestry groups and whether this can explain cancer-specific molecular differences observed across these groups (CellPress)
  • WGS of tumour and peripheral blood samples of primary breast cancer patients reveals divergence of mutational signatures (Molecular Carcinogenesis)
  •  RNA methylation modification patterns play key role in ischemic stroke, and could offer diagnostic and therapeutic targets for future research (Frontier in Genetics)
  • Researchers develop a novel long non-coding RNA molecule that shows therapeutic potential with limited off-target effects for use in future studies (Oncoscience)
  • Computational tools enable genomic and transcriptomic holistic view of breast cancer, identifying 16 hub genes related to good prognosis (Frontier in Genetics)
  • Largest WGS melanoma study to date provides etiological and biological insights into multiple subtypes, revealing potential novel germline predisposition genes for less common types (Cancer Discovery)
  • Researchers find that opposing cytoskeletal forces drive lytic granule polarization, shaping T cell synapse topography and ultimately impacting how effectively perforin can target tumour cell membranes (Developmental Cell)

In other news:

  • Three papers in science highlight the potential exciting new directions for machine learning technology in enabling protein design, pointing to advances in vaccines, treatments, tools for carbon capture, and many other areas (ScienceDaily)
  • Large observational study links ADHD with increased risk of cardiovascular diseases – those with the condition found to have twice the risk of developing at least one cardiovascular disease compared to those without (World Psychiatry)

More on these topics

Cancer / Genomics / Week in brief