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Genomics week in brief: Week ending 17th June

Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space!

Top stories from the past week

  • Researchers detected and characterised male sex chromosome abnormalities in the UK Biobank study (Zhao et al)
  • Comparative transcriptomics revealed circadian and pluripotency networks as two pillars of longevity regulation. (Lu et al)
  • Researchers found a novel miRNA pathway that could treat osteoporosis. (Huang et al)
  • A new study explored the looping model for enhancer-promoter communication and transcription regulation in mammals. (Popay et al)
  • A proof-of-concept study used metagenomic DNA sequencing for semi-quantitative pathogen detection from urine. (Janes et al)
  • Blood-based untargeted metabolomics in multiple sclerosis revealed a testable therapeutic target. (Zahoor et al)
  • Researchers identified a novel anti-CRISPR mechanism and structure. (Ren et al)
  • A genetic study of patients with myeloproliferative neoplasms has led to the creation of a new peptide cancer vaccine. (Gigoux et al)
  • A new study discovered the long noncoding RNA gene that is a key regulator in the parasite that causes African sleeping sickness, opening new therapeutic strategies. (Guegan et al)
  • Interim results from a CAR T-cell therapy showed early promise for gastrointestinal cancer. (Larkin)
  • Researchers presented a pan-cancer compendium of chromosomal instability, helping predict drug response and identify drug targets. (Drews et al)
  • Neurologists highlighted the importance of genomics in advancing the diagnosis and treatment of dementia. (Decourt et al)
  • Multilevel atlas comparisons revealed divergent evolution of the primate brain. (Garin et al)
  • Researchers found that RNA induces unique tau strains and stabilises Alzheimer’s disease seeds. (Zwierzchowski-Zarate et al)
  • Researchers from Feinberg School of Medicine North-western University presented a deep-learning framework for detecting a full range of structural variations from bulk and single-cell contact maps. (Wang et al)
  • A new study identified variants contributing to breast cancer onset and metastasis. (Nierenberg et al)

In other news:

  • Research must do no harm: new guidance addresses all studies relating to people. (Nature)
  • Monkeypox in 2022 – what clinicians need to know. (Guarner et al)
  • A complete, telomere-to-telomere human genome sequence presents new opportunities for evolutionary genomics. (Nature Methods)
  • One epigenome-editing injection could cut cholesterol level for years. (New Scientist)
  • Real age versus biological age: the start-ups revealing how old we really are. (Guardian)
  • Huge plan to map the DNA of all life in British Isles. (BBC News)
  • New CRISPR-based map ties every human gene to its function. (MIT News)
  • African genomes hold key to global genetic medicine. (Genetic Literacy Project)
  • DNA, Dollars, and Dilemmas – should advances in DNA sequencing go the way of Waze and credit cards?  (Medium)
  • Getting closer to a vaccine for cancer: new approaches make researchers optimistic about success. (Washington Post)

Image credit: canva

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Cancer / Gene Editing / Genomics / Week in brief