Welcome back to Week in Brief, where you can get the latest updates from the genomics world and beyond!
How do circulating proteins influence our health and well-being?
A study has shown that levels of a circulation protein, CD74, could predict treatment outcomes for those with bowel cancer. Specifically, the test could indicate whether an individual is likely to respond to immunotherapy (Cancer Cell).
A protein involved in embryonic development – and previously linked to female fertility – has been shown to contribute to abnormal sperm morphology and decreased sperm count in male mice, according to a new study (Frontiers in Cell & Developmental Biology).
A study in mice has shown that a protein, known as STELLA, can disrupt a key epigenetic factor that drives the development of colorectal cancer. The study showed that the mouse version of the protein works better than the human version, and the researchers are working to adapt this protein as a cancer treatment (Nature Communications).
DNA damage has been the topic of new research…
A recent study has revealed that certain types of DNA damage can persist for significant periods of time, without being repaired. This means that there are more chances for harmful, cancer-causing mutations to arise (Nature).
New research has shed light on the mechanisms behind Huntington’s disease. The work revealed that the repeat expansion mutation that causes the condition only becomes toxic in later life, suggesting that treatments to delay further expansion could be effective (Cell).
Genes and environmental factors have been linked…
Researchers have discovered a gene expressed in the brain that is linked to obesity. This gene, OTP, is thought to regulate the expression of another gene known to control hunger, and could open new treatment avenues (Science Translational Medicine).
Individuals who get divorced tend to have higher genetic risk for certain psychiatric disorders, according to a new study. This observation is true even in those who do not ever develop these conditions (Clinical Psychological Science).
What else has gone on this week?
Using base editing, researchers have successfully developed a gene therapy that is able to extend the lifespan of mice with prion disease (Nature Medicine).
New work has revealed the mutational landscape of Staphylococcus aureus, which is known to colonise the human body. The research has shed light on the genes that allow the bacteria to adapt to this environment, and, for example, to acquire antibiotic resistance (Nature Communications).
Scientists have shown that a combination of ctDNA analysis and comprehensive genomic profiling can effectively predict cancer treatment response and relapse. This could opens doors for more effective use of precision treatments (Cancer Research).
A new study has shown that there are differences in gene activity in the nasal mucosa of those who suffer from birch pollen allergies and those who do not. This finding could contribute to better treatments for this common allergy (Allergy).
Check out last week’s Week in Brief here.
