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Genomics week in brief: Week ending 16th October

Delve into some of the latest genomics news and research from the past week in this week’s Genomics Week in Brief.

Top stories from the past week

  • A new study has found genes that play a key role in exercise outcomes. (Chung et al, 2021)
  • Researchers have developed a new way to mimic micro-environments in the human body to overcome a major challenge in using phage therapy to fight antibiotic resistance. (Attrill et al, 2021)
  • For the first time, researchers have identified DNA mutations in liver cells that impact metabolism and insulin sensitivity in patients with liver disease. (Ng et al, 2021)
  • New findings reveal the association of four genetic variants with colorectal cancer in the Kazakhstan population. (Kolesnikova et al, 2021)
  • Researchers have predicted the expected reduction in complex disease risk following polygenic embryo screening for a single disease. (Lencz et al, 2021)
  • Computational scientists at the Salk Institute for Biological Studies have combined gene mutation information with cancer prevalence data to uncover the genetic basis of cancer in the entire population of cancer patients in the United States. (Mendiratta et al, 2021)
  • Researchers in Qatar have unveiled a high-resolution map of the genetic structure of Arab and Middle Eastern populations. These findings have shed light on the population structure and genetic diversity of modern Arab and Middle Eastern populations. (Razali et al, 2021)
  • A researcher has discovered an enzyme, USP15, that plays a key role in the ability of cancer cells to develop resistance to drug treatment. (Nguyen, 2021)
  • New research has revealed how the common respiratory virus, respiratory syncytial virus (RSV), can manipulate immune genes to protect itself. (Pei et al, 2021)
  • In a recent study, researchers have identified a new detrimental effect of genes that result in inherited diseases. (Di et al, 2021)
  • A new machine-learning algorithm has illustrated at high-definition how genomes organise in single cells. (Zhang et al, 2021)
  • Researchers have harnessed CRISPR/Cas9-directed epigenetic editing to characterise the transcriptional changes and the functional effects on cell fate in different tumour settings. (Vizoso and Rheenen, 2021)
  • UCLA researchers have provided an update on patients treated for adenosine deaminase–deficient severe combined immunodeficiency using gene therapy between 2009 and 2012. (Reinhardt et al, 2021)
  • Researchers have finally revealed the molecular causes of a particular type of food-dependent Cushing’s Syndrome (a rare disease affecting both adrenal glands). (Chasseloup et al, 2021)
  • New findings have reported the role of a protein complex, mTORC2, in preventing brain damage from herpes simplex virus 1. (Suryawanshi et al, 2021)

In other news

  • The Centers for Disease Control and Prevention’s (CDC) Genetic Testing Reference Material Program (GeT-RM) and the Clinical Genome Resource (ClinGen) have partnered to develop a publicly available list of 546 expert curated pathogenic variants in 84 genes for use in next-generation sequencing genetic testing. (Wilcox et al, 2021)
  • The University of California (UC) San Diego School of Medicine researchers have been awarded $11.7 million to launch the Genetic & Social Determinants of Health: Center for Admixture Science and Technology (CAST), which will focus on the genetics of people of admixed ancestry.  (UCSD Health, 2021)

Image credit: canva