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Genomics week in brief: Week ending 13th February

The latest ‘Genomics week in brief’ filled with the most recent genomics news and research from the past week!

Top stories from the past week

  • A new study suggests that differences in the expression of gene transcripts may be key to understand how mental disorders with shared genetic risk factors result in different patterns of onset, symptoms, course of illness and treatment responses. (Akula et al, 2021)
  • Researchers have developed a new and more complete dog reference genome. (Wang et al, 2021)
  • A team have established nine permanent colon CTC lines from peripheral blood samples of a patient with metastatic colon cancer and compared their transcriptomic profiles to identify changes in expression linked to treatment pressure. (Alix-Panabières et al, 2021)
  • A new study has provided insight into why Black men’s prostate cancer may be more responsive to immunotherapy, paving the way to precision medicine. (Schaeffer et al, 2021)
  • Mutations in one of the BAF complex genes are common in human cancers. Researchers have investigated this complex in more detail, showing how quickly changes in the BAF complex genes influence the accessibility of DNA. (Schick et al, 2021)
  • Rice University researchers have programmed a modified CRISPR/Cas9 complex to target specific histones with pinpoint accuracy. (Hilton et al, 2021)
  • Recent genetic data from Huntington’s disease patients shows that DNA repair is an important factor that determines how early or late the disease occurs in individuals with expanded CAG repeats in the HTT gene. (Pyo et al, 2021)
  • According to new research, a commercially available genomic test may help oncologists better determine which patients with recurrent prostate cancer may benefit from hormone therapy. (Spratt et al, 2021)
  • A recent GWAS for Addison’s disease has identified multiple risk loci in disease susceptibility. (Husebye et al, 2021)
  • A machine-learning study conducted by researchers at the Wyss Institute in collaboration with Google Research has enabled unprecedented AAV capsid diversification with potential for improving gene therapies. (Bryant et al, 2021)


  • Join us for our new three-part webinar series – ‘Microbiome Sequencing ONLINE‘ – where we explore how metagenomics and microbiome sequencing is uncovering the hidden traits of the invisible world. The next webinar is taking place on Thursday 18th February 3pm GMT/4pm CET/10am EST. Register now.

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