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Genomics week in brief: Week ending 10th April

Enjoy the latest genomics week in brief, filled with all of the most recent genomics news and research!

Top stories from the past week

  • Researchers have developed a new RNA-sequencing method – PANDORA-seq – that helps discover previously undetectable modified small RNAs. (Shi et al, 2021)
  • Using ancient genomes, researchers have shed new light on the earliest Europeans and their relationships with Neanderthals. (Hajdinjak et al, 2021)
  • Researchers have developed a new method that enables nanopore sequencing for broadly applicable methylation discovery. (Tourancheau et al, 2021)
  • New technology – CRISPR-SNP-Chip – is able to detect single point mutations without amplification. (Balderston et al, 2021)
  • Mutations in the OPHN1 gene can cause a rare X-linked disease that includes poor stress tolerance. Researchers have found three ways to reverse the effects of this mutated gene in mice. (Wang et al, 2021
  • Researchers have found that an important defect in STING gene expression in melanoma cells enables it to evade the immune system. (Falahat et al, 2021)
  • Scientists have found that colorectal cancer patients with particular mitochondrial DNA mutations in their tumours had a 57-93% decreased risk of death. (Gorelick et al, 2021)
  • Around 1% of people with Alzheimer’s disease carry a mutation in the PLD3 gene. Now, researchers have found that this mutation puts people at a higher risk of developing the disease by disrupting its role in the lysosome. (Nackenoff et al, 2021)
  • Researchers have discovered that transposons can protect against blood cancers. (Gu et al, 2021)
  • A team at the Francis Crick Institute has found that blocking protein DNPH1 could increase tumour sensitivity to treatment with PARP inhibitors. (Fugger et al, 2021)


  • Check out our latest webinar series – ‘Cancer Genomics ONLINE’. In this series, we share work from global researchers who are mapping cancer genomes and leading the fight against this disease. The first webinar is taking place on Thursday 15th April at 3pm BST/4pm CEST/10am EDT. Register now to watch the webinar live or on-demand.
  • Join us on Wednesday 14th April at 3pm BST/4pm CEST/10am EDT for our recent webinar series – ‘COVID & Genomics ONLINE‘. Here, we share the latest research and insights from leading experts covering key aspects of the pandemic. Register now to watch the webinar live or on-demand.

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