Could the 3D epigenome hold the answers for difficult-to-treat diseases?
Epigenetic therapeutics are promising for diseases, such as cancer and neuropsychiatric disorders, as they provide a novel target for therapy. Yet there are challenges going from epigenetic data to developing drugs to seeing clinical applications.
The brand-new Epigenetics in Healthcare & Disease Webinar Series will put epigenetic therapy at centre stage, driving into novel preclinical models, and the generation of large datasets from a wide variety of patient populations.
Register to the Epigenetics in Healthcare & Disease webinar here
**Please note that by registering for one webinar in the series, you will automatically be registered to all subsequent webinars**
Over the next three Tuesdays (1s, 8th and 15th October 2024 at 3pm BST / 4pm CET / 10am EDT), 9 experts across 3 webinars will tackle challenges in epigenetic data, therapeutics and translational models, along the path to epigenetically-informed treatments.
This webinar series will help you to:
- Learn to generate and analyse large-scale epigenomics data from various patient populations
- Discover new preclinical models that allow the recapitulation of the disease microenvironment
- Uncover epigenetic risk assessment, preventative measures and novel therapeutics interventions for cancer treatment
Webinar 1: Harnessing Epigenetic & Epigenomic Data to Better Understand Disease Pathology
Tuesday 1st October at 3pm BST / 4pm CET / 10am EDT (Sponsored by biomodal)
Recent advancements in epigenetic and epigenomic sequencing of large sets of regions have led to substantial improvement in accuracy, throughput and read length of DNA and RNA molecules.
This webinar will explore improvements in bioinformatics analysis of large-scale epigenetic data acquired from a wide range of patient populations with various diseases.
Webinar Talks:
Generating Meaningful Epigenomic Data from Larger Patient Populations to Better Understand Disease Biology
- Miten Jain, Associate Professor, Northeastern University
Reveal the power of the 6-base genome for transformative insights into current and future states of disease
- Tom Charlesworth, Director, Market Strategy and Corporate Development, biomodal.
Epigenetic Profiling using Nanopore Sequencing Data for Improved Patient Stratification & Highlighting Underlying Mechanisms Crucial for Cancer Progression & Disease Prognosis
- Gianluca Mattei, Post-Doctoral Research Fellow, University of Florence
You will learn:
- A summary of the state of the art with DNA and methylation analysis
- Uncover the variety of data analysis tools and get advice on what to use
- Review the strengths and limitations of nanopore sequencing for methylation profiling
Webinar 2: The Latest in Epigenetic Therapeutics & Anti-Cancer Treatments
Tuesday 8th October at 3pm BST / 4pm CET / 10am EDT
Epigenetic influences on gene expression are a beacon of opportunity for therapeutic interventions for many diseases. Yet, there are still major challenges, such as resistance and unfavourable side effects, that need to be overcome.
Join this webinar to explore the promise of combination therapy to tackle drug resistance and to improve your understanding of the 3D chromatin structure in order to develop novel epigenetic therapeutics.
Webinar Talks:
Examining the Potential of Epigenetic Combination Therapy to Overcome Treatment Resistance in Oestrogen Receptor-Positive Breast Cancer
- Dalia Rosano, Research Associate, Institute of Cancer Research, London
Exploring Epigenetic Approaches to Understand Cancer Aetiology & Develop Risk Assessment Tools for Prevention & Early Intervention
- Mukesh Verma, Chief, Cancer Epidemiology & Genomics Research Program, NCI (NIH)
Understanding the Link Between Epigenome & 3D Chromatin Structure to Design & Develop Novel Therapeutics
- Giovanni Gambi, Post-Doctoral Fellow, NYU Grossman School of Medicine
You will learn:
- How to identify multi-connected enhancer/promoter elements (3D hubs) and screening by CRISPR interference
- About novel tools and technologies in epigenetics and risk assessment, and uncovering intervention and cancer control
- The process for genetic, phenotypic and epigenomic profiling of cells exposed to endocrine therapies
Webinar 3: Bridging the Translational Gap: Recapitulating Disease Epigenetics with Modified Models Tuesday 15th October at 3pm BST / 4pm CET / 10am EDT
Despite their utility, no animal model has yet recapitulated every aspect of a disease. Animal models are usually based on one genetic variant which causes an obstacle when scientist attempt to produce multi-genetic models on a larger scale.
This webinar is your opportunity to learn how you can tackle these obstacles with the development of novel iPSC-derived cell lines and tissue models that recapitulate disease epigenetics to better showcase drug safety and efficacy and for a smoother transition into the clinic.
Webinar Talks:
Designing Epigenetically Modified Mouse Models to Understand Transgenerational Inheritance of Epigenetic Signatures in Mammals to Reduce Familial Disease Risk
- Yuta Takahashi, Associate Professor, Gene Expression Laboratory, Salk Institute for Biological Studies
Developing iPSC Neurons & Patient Lymphocytes to Understand Underlying Epigenetic Mutations in DNA Damage & Repair Mechanisms in Schizophrenia & Other Bi-Specific Neuropsychiatric Diseases
- Martin Higgs, Deputy Director, Centre for Rare Disease Studies, University of Birmingham
Developing Novel Translational Rat & Mouse Models to Understand the Epigenetic Regulation of Stress in Depression
- Chris Murgatroyd, Professor of Epigenetics, Manchester Metropolitan University
You will learn:
- About the processes and experiences from generating epigenetically-edited mice and IPSC neurons
- How to evaluate the impact of histone modifications on DNA repair
- Ways to monitor the epigenetic regulation of stress
