This talk was recorded at the Mathematical Institute, University of Oxford on 28th November 2019. Professor Dame Sue Hill OBE PhD DSC CBiol FRSB Hon FRCP Hon FRCPath is the Chief Scientific Officer for England, providing expert clinical scientific advice across the health system. She is head of profession for the healthcare science workforce in the NHS and associated bodies, embracing more than 50 separate scientific specialisms. Sue is the Senior Responsible Officer for Genomics in NHS England, leading developments in this area, having previously established the NHS Genomic Medicine Centres and led the NHS contribution to the 100,000 Genomes Project. She is a respiratory scientist by background with an international academic and clinical research reputation.