Genomics research has been rapidly transforming our understanding and ability to treat cancer. Today, novel techniques are enabling the development of tailored precision drugs in the clinic and benefitting patients around the world.
This report will provide you with:
- An introduction to how genomics influences cancer biology
- An overview of the challenges associated with translating cancer genomics research into clinical implementation
- Insights into the current status and future directions of clinical cancer genomics and precision oncology
Report contributors include:
- Alastair Greystoke, Clinical Senior Lecturer/Hon Consultant, Newcastle University/ Newcastle upon Tyne Hospitals Trust
- Anju Kulkarni, Consultant Clinical Geneticist, Guy’s and St Thomas’ NHS Foundation Trust
- Donald White, Precision medicine manager, Cancer Research UK
- Gary Middleton, Professor, University of Birmingham
- Maria Antoinetta Cerone, Portfolio Manager, Cancer Research UK
- Pauline Rehal, Principal Clinical Scientist, West Midlands Regional Genetics Laboratory
Chapter 1: Cancer Biology
This chapter highlights cancer as a disease of the genome and it explains how our understanding of its genetic background is growing through many areas of research, such as cancer genome evolution and the tumour microenvironment.
Chapter 2: Enabling Technologies
This chapter showcases some of the technologies that are helping to elucidate cancer research, such as single cell analysis, spatial transcriptomics and genome editing techniques.
Chapter 3: Cancer Diagnostics
This chapter features the usefulness of genomics in cancer diagnostics, including liquid biopsy, and how this can aid in the transformation of cancer care.
Chapter 4: Precision Oncology
This chapter highlights the origin of precision oncology and what the new techniques are promising from a clinical perspective.
Chapter 5: Challenges and Future Directions
Genomics has the power to enhance our understanding of cancer and positively influence our approach to clinical care of the disease. However, reaching the full potential of cancer genomics remains challenging.
This chapter highlights these difficulties and presents the future directions of cancer genomics.
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