We frequently read articles about how diseases have been reversed, halted and cured in mice, yet effective treatments for humans are still lacking. So, how can we better mimic human disease to advance research into potential therapies and develop new research models along the way? I3D-tissue cultures, for example, are a science reality that propel our ability to accurately mimic organ function and serve as an avatar of patients for precision medicine. These tissues can also be transplanted back into patients, offering new opportunities for therapies.
In this webinar series, we will explore the various uses of 3D tissue cultures and their potential uses in biomedical applications. We will examine the latest research and innovations in this field and discuss the challenges and opportunities for further development.
Each session will also include live Q&A with the speakers.
** Please note, by registering for webinar one, you will automatically receive access to the subsequent webinars in the series.**
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Thursday 9 March at 3pm GMT / 4pm CET / 10am EST
Whilst animal models have been useful for simulating diseases, they can be time-consuming to generate and may not always accurately predict drug efficacy or toxicity in humans. 3D tissue models, such as organoids, are increasingly being used to test the effectiveness and safety of drugs, as well as to study the underlying mechanisms of diseases.
In this webinar, we will discuss the advantages and limitations of organoid cultures with a specific focus on their applications for functional genomics studies.
- Talk 1: Patient-derived organoids in functional genomics
- Luigi Aloia, Associate Director, Advanced Cell Models, Functional Genomics, AstraZeneca
- Talk 2: Accelerating Alzheimer’s drug discovery using mechanism-based 3D human cellular models
- Doo Yeon Kim, Associate Professor, Harvard Medical School
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Thursday 16 March at 3pm GMT / 4pm CET / 11am EST
The last decade has produced huge developments in drug discovery. One major hurdle that remains is translating scientific findings into effective treatments. To overcome this challenge, researchers need models that more closely resemble human tissues. 3D cultures, such as organoids, offer an important solution by providing more physiologically-accurate human tissue models that are easier to image than animal models. However, organoids are opaque and spatially resolved, therefore advanced imaging techniques are required to visualise them. In this webinar, we will examine how researchers are using the benefits of organoids to develop better models of disease and how they are using ‘instant volume’ imaging to capture organoids in real-time.
- Talk1: 3D+time microscopy of organoids: challenges and solutions
- Florian Strohl, Principal Investigator, The Arctic University of Norway
- Talk2: An Engineered Multicellular Stem Cell Niche for Studying Disease, Aging, and Regeneration
- Omid Mashinchian, R&D team lead and senior scientist, Nestlé Institute of Health Science
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Thursday 23 March at 3pm GMT / 4pm CET / 11am EST
It is now possible to have an organ on a chip that recapitulates in vivo behaviour. These 3D microfluidic cell cultures, known as ‘organs-on-a-chip,’ have the potential to replace the need for animal testing in drug development. They can be used to simulate infections, model diseases and test the toxicity and effectiveness of drugs, as well as the interactions between different drugs. In this webinar, we will explore the various ways in which organs-on-a-chip can be used in drug development and testing.
- Talk 1: Organ-on-a-chip to study the crosstalk between organotypic primary human 3D tissues
- Volker Lauschke, Associate Professor in Personalized Medicine and Drug Development, Karolinska Institutet & Deputy Head of the Margarete Fischer-Bosch Institute of Clinical Pharmacology
- Talk2: In vitro modelling of rare mitochondrial and peroxisomal diseases
- Vivian Gama, Associate Professor, Vanderbilt University