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Genome-wide CRISPR and tumour suppressor genes could open new pathways for discovering anticancer drugs

Researchers at the University of Texas have performed genome-wide CRISPR screens to uncover vulnerabilities critical for discovering anticancer drugs. The […]

Targeting p53 for Successful Tumour Suppression

Exposure to radiation can wreak havoc on cells, tissue and organs. However, some tissues are more vulnerable to radiation damage […]

Evolutionary arms race: artificial selection for host resistance to tumour growth

Researchers have used artificial selection to observe the evolutionary arms race between tumour cells and the host immune response. Evolutionary […]

Some male-derived cancers inactive the X chromosome

Another layer of complexity has been added to the process of oncogenesis – a normally female-specific developmental process, called X […]

p53 controls cell metabolism to prevent genomic instability

p53 has long been called the “guardian of the genome,” but how is this tumour suppressor protein maintaining genomic stability […]

Multi-omics study identifies two major subgroups of cervical cancer

In the largest omics study of its kind, a team of researchers have identified two distinct molecular subgroups of cervical […]

Scientists discover “super enhancer” gene linked to colorectal cancer

Researchers at Mount Sinai’s Tisch Cancer Institute have demonstrated the first evidence linking the tumour microenvironment to a “super enhancer” […]

A Spotlight On: Cancer Epigenetics – Andy Sharrocks

Andy Sharrocks (Professor at The University of Manchester) joins us to discuss the epigenetics of esophageal adenocarcinoma, why studying epigenetics […]

GMSCs stem cells found to retain quality with age

New research has discovered how dental tissue stem cells retain their growth and immunomodulatory characteristics, even in older donors, offering […]

Spinning a Yarn with the p53 Cancer Protein

Written by Charlotte Harrison, science writer  The tumour suppressor protein p53 is a key controller of cell proliferation. Mutations that […]