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CAR T-cells activated by heat destroy solid tumours

Despite its success against liquid tumours, CAR T-cell therapy often has no impact on solid tumours. A new study, published […]

A new strategy to combat solid tumours with neoantigen-based immunotherapy

A preclinical study has provided in vitro and in vivo evidence for using mutated KRAS epitopes as a viable target […]

Pan-cancer tumour organoids pave the way towards precision medicine

Researchers have developed a platform of pan-cancer tumour organoids and a neural-network-based drug assay, that has the potential to advance […]

Genetics Unzipped podcast: Catching cancer – Transmissible tumours in dogs, devils, clams and cannibal hamsters

In the latest episode of Genetics Unzipped, presenter Dr Kat Arney reads an exclusive excerpt from her recent book, Rebel […]

Resolving the driving forces behind tumour heterogeneity

Researchers have recently developed an in vitro model that can distinguish between the genetic, epigenetic and stochastic factors underlying tumour […]

Blood stem cells are linked to the progression of aggressive brain tumours

Using transcriptome analysis and gene expression sequencing, researchers have discovered that blood stem cells (HSPCs) cause increased cell division in […]

New algorithm detects tumour weaknesses

A new study funded by Cancer Research UK and published in Nature Cancer has described a new algorithm – called […]

Intra-tumour heterogeneity across human cancer genomes

As part of the Pan-Cancer Analysis of Whole Genomes Consortium, researchers analysed the whole genomes of tumour samples from over […]

Targeting p53 for Successful Tumour Suppression

Exposure to radiation can wreak havoc on cells, tissue and organs. However, some tissues are more vulnerable to radiation damage […]

New Biomarkers of Childhood Brain Tumours Identified in Cerebrospinal Fluid

Paediatric brain tumours are the leading cause of tumour-related mortality in children. There is a widespread search for predictive biomarkers […]