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Transcriptome and circular DNA sequencing in single cancer cells

A new single-cell sequencing method has been published in Nature Genetics. Single-cell extrachromosomal circular DNA and transcriptome sequencing (scEC&T-seq) can […]

New method improves next-generation sequencing accuracy 1000-fold

A new method has been published in Nature Genetics that offers a 1000-fold increase in accuracy compared to next-generation sequencing […]

The Sequencing Buyer’s Guide: 5th Edition

In recent years, next-generation sequencing (NGS) has evolved from a technology used purely in research settings to being a key […]

Sequencing options for cancer genomics

We’ve come a long way since the dawn of Sanger sequencing in 1977. The rapid development of next-generation sequencing (NGS) […]

Comprehensive sequencing of the small intestine reveals “collateral damage” by APOBEC1 enzyme may lead to cancer

Researchers at the Wellcome Sanger Institute have found that the enzyme APOBEC1 may cause the mutations SBS2 and SBS13 – […]

A guide to single-cell sequencing and spatial analysis

Introduction The human body contains over 35 trillion cells, with tissues and organs comprising of many different cell types constantly […]

An overview of single-cell RNA sequencing and spatial transcriptomics

Single-cell RNA sequencing (scRNA-seq) has become the most established and widely used technique within single-cell analysis. Spatial transcriptomics is quickly […]

RNA-sequencing of amniotic fluid cells for prenatal diagnosis of rare disorders

A team of researchers from Hong Kong have developed a proof-of-concept RNA-sequencing approach to analyse amniotic fluid to diagnose rare […]

Single nucleus RNA sequencing reveals potential treatment for Huntington’s disease

In a recent paper, published in Nature Communications, a team of scientists used single nucleus RNA sequencing (snRNAseq) to investigate […]

Multimodal tissue characterisation with spatial protein and transcriptome sequencing

A new study, published in Nature Biotechnology, presents Spatial PrOtein and Transcriptome Sequencing (SPOTS) for high throughput combined spatial transcriptomics […]