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New Commercial Developments in Single-cell Sequencing

This feature on single-cell sequencing technology is adapted from parts of Chapters 1 & 2 of the 2023 Spatial and […]

Methods to study cell-cell communication from single-cell sequencing data

This feature on cell-cell communication is adapted from part of Chapter 4 of the 2023 Spatial and Single-cell Playbook. Organisms […]

Genomic sequencing fine-tunes prostate cancer diagnosis

A study from Nature Medicine has significantly refined the use of prostate-specific antigen (PSA) screening for prostate cancer using an […]

Transcriptome and circular DNA sequencing in single cancer cells

A new single-cell sequencing method has been published in Nature Genetics. Single-cell extrachromosomal circular DNA and transcriptome sequencing (scEC&T-seq) can […]

New method improves next-generation sequencing accuracy 1000-fold

A new method has been published in Nature Genetics that offers a 1000-fold increase in accuracy compared to next-generation sequencing […]

The Sequencing Buyer’s Guide: 5th Edition

In recent years, next-generation sequencing (NGS) has evolved from a technology used purely in research settings to being a key […]

Sequencing options for cancer genomics

Original post by Liam Little in February 2023. Updated by Ashleigh Davey in September 2023. Over the last decade, the […]

Comprehensive sequencing of the small intestine reveals “collateral damage” by APOBEC1 enzyme may lead to cancer

Researchers at the Wellcome Sanger Institute have found that the enzyme APOBEC1 may cause the mutations SBS2 and SBS13 – […]

A guide to single-cell sequencing and spatial analysis

Introduction The human body contains over 35 trillion cells, with tissues and organs comprising of many different cell types constantly […]

An overview of single-cell RNA sequencing and spatial transcriptomics

Single-cell RNA sequencing (scRNA-seq) has become the most established and widely used technique within single-cell analysis. Spatial transcriptomics is quickly […]