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Search results for: Polygenic risk score

Schizophrenia polygenic risk scores: The struggle of improving their clinical utility

Researchers have analysed clinical and genetic data from over 8,500 adults with psychiatric disorders, to assess whether schizophrenia polygenic risk […]

Guidelines for reporting polygenic risk score

Researchers from NIH have developed a 22-item framework, published in Nature, that has identified the minimal polygenic risk score-related information […]

Improving polygenic risk scores

Existing genome-wide association studies have been predominantly conducted in individuals of European descent. In turn, this has limited the transferability […]

How to: perform polygenic risk score analysis

A recent article published in Nature Protocols highlights key issues related to polygenic risk score analyses and provides a starting […]

Polygenic background modifies penetrance of monogenic variants

Researchers have found that polygenic background can modify penetrance of disease in tier 1 genomic conditions. Monogenic variants Monogenic variants […]

Combined risk score predicts type 1 diabetes in children

An article published in Nature Medicine has demonstrated that a combined risk score improves type 1 diabetes (T1D) prediction in […]

Genetic risk for Alzheimer’s progression differs with sex

It is well documented that the genetic risk for Alzheimer’s has a sex bias. Sex bias in Alzheimer’s Carrying a […]

Opinion: Do not rely on your genes to fit into your jeans, genetics-based nutrition is risky business!

Recent times has seen an influx in companies offering direct to consumer genetic tests that offer a wide range of […]

Longevity pathways identified in exome analysis of centenarians

Non-human model organisms have provided evidence to suggest that rare protein-coding variants in pathways linked to longevity can guard against […]