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Moving Polygenic Risk Scores into the Clinic

Genetic testing is widely used to diagnose monogenic diseases that are caused by mutations in a single gene, such as […]

Sepsis-Associated Variants Integrated into Polygenic Risk Score

Written by Vered Smith, Science Writer  Researchers at the University of Michigan have published a study in PLOS ONE identifying […]

Schizophrenia polygenic risk scores: The struggle of improving their clinical utility

Researchers have analysed clinical and genetic data from over 8,500 adults with psychiatric disorders, to assess whether schizophrenia polygenic risk […]

Guidelines for reporting polygenic risk score

Researchers from NIH have developed a 22-item framework, published in Nature, that has identified the minimal polygenic risk score-related information […]

Improving polygenic risk scores

Existing genome-wide association studies have been predominantly conducted in individuals of European descent. In turn, this has limited the transferability […]

How to: perform polygenic risk score analysis

A recent article published in Nature Protocols highlights key issues related to polygenic risk score analyses and provides a starting […]

Exome sequencing in bipolar disorder identifies new risk gene

A study published in Nature Genetics from a consortium of researchers — the BipEx collaboration — is the largest whole-exome […]

GWAS identifies new acne risk genes

A genome-wide association study (GWAS) of acne has identified 29 regions of the genome that influence the condition. Acne vulgaris […]

The low portability of polygenic scores using UK Biobank data

Using data derived from the UK Biobank, researchers have found that polygenic scores have low portability between genetic populations. Polygenic […]