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Search results for: Polygenic risk score

How to: perform polygenic risk score analysis

A recent article published in Nature Protocols highlights key issues related to polygenic risk score analyses and provides a starting […]

Polygenic background modifies penetrance of monogenic variants

Researchers have found that polygenic background can modify penetrance of disease in tier 1 genomic conditions. Monogenic variants Monogenic variants […]

Combined risk score predicts type 1 diabetes in children

An article published in Nature Medicine has demonstrated that a combined risk score improves type 1 diabetes (T1D) prediction in […]

Genetic risk for Alzheimer’s progression differs with sex

It is well documented that the genetic risk for Alzheimer’s has a sex bias. Sex bias in Alzheimer’s Carrying a […]

Opinion: Do not rely on your genes to fit into your jeans, genetics-based nutrition is risky business!

Recent times has seen an influx in companies offering direct to consumer genetic tests that offer a wide range of […]

Genetic variants linked to male breast cancer found

A recent study published in the Journal of the National Cancer Institute has discovered three genetic variants linked to an […]

Machine learning identifies epigenetic markers of Schizophrenia

We know from twin studies that Schizophrenia carries a 80% heritability risk, but haven’t yet managed to deduce exact genetic […]

Interview with Rory Collins, Principal Investigator and Chief Executive of UK Biobank

Rory Collins, Principal Investigator and Chief Executive of UK Biobank leads this landmark project. We talk to him about some of the research outcomes from UK Biobank, and why he’s excited to be speaking at the Festival of Genomics this January.

TWAS: Transcriptome-wide association study

A recent trend in large-scale association studies is transcriptome-wide association study (TWAS), which aggregates genomic information into functionally relevant units […]