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Schizophrenia polygenic risk scores: The struggle of improving their clinical utility

Researchers have analysed clinical and genetic data from over 8,500 adults with psychiatric disorders, to assess whether schizophrenia polygenic risk […]

Improving polygenic risk scores

Existing genome-wide association studies have been predominantly conducted in individuals of European descent. In turn, this has limited the transferability […]

Guidelines for reporting polygenic risk score

Researchers from NIH have developed a 22-item framework, published in Nature, that has identified the minimal polygenic risk score-related information […]

Polygenic background modifies penetrance of monogenic variants

Researchers have found that polygenic background can modify penetrance of disease in tier 1 genomic conditions. Monogenic variants Monogenic variants […]

Genetic risk for Alzheimer’s progression differs with sex

It is well documented that the genetic risk for Alzheimer’s has a sex bias. Sex bias in Alzheimer’s Carrying a […]

Longevity pathways identified in exome analysis of centenarians

Non-human model organisms have provided evidence to suggest that rare protein-coding variants in pathways linked to longevity can guard against […]

World of Genomics: Germany

In this week’s World of Genomics entry, we explore Deutschland, also known more commonly as Germany. Despite the strength of […]

Analysis of 1.5 million people identifies genes related to antisocial behaviours

A new study, published in Nature Neuroscience, has analysed data from 1.5 million people to identify genes underlying behaviours related […]

A Spotlight On: Science Communication – Jonathan Roberts

Jonathan Roberts is a Registered Genetic Counsellor at Addenbrooke’s Hospital in Cambridge and a Researcher at the Society and Ethics […]