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Moving Polygenic Risk Scores into the Clinic

Genetic testing is widely used to diagnose monogenic diseases that are caused by mutations in a single gene, such as […]

Schizophrenia polygenic risk scores: The struggle of improving their clinical utility

Researchers have analysed clinical and genetic data from over 8,500 adults with psychiatric disorders, to assess whether schizophrenia polygenic risk […]

Improving polygenic risk scores

Existing genome-wide association studies have been predominantly conducted in individuals of European descent. In turn, this has limited the transferability […]

Sepsis-Associated Variants Integrated into Polygenic Risk Score

Written by Vered Smith, Science Writer  Researchers at the University of Michigan have published a study in PLOS ONE identifying […]

The low portability of polygenic scores using UK Biobank data

Using data derived from the UK Biobank, researchers have found that polygenic scores have low portability between genetic populations. Polygenic […]

A Spotlight On: Polygenic Embryo Screening – Dr. Todd Lencz, Professor at the Feinstein Institutes for Medical Research

Dr Todd Lencz is a Professor at the Feinstein Institutes for Medical Research in Manhasset, New York. Lencz’s team were […]

Guidelines for reporting polygenic risk score

Researchers from NIH have developed a 22-item framework, published in Nature, that has identified the minimal polygenic risk score-related information […]

Polygenic background modifies penetrance of monogenic variants

Researchers have found that polygenic background can modify penetrance of disease in tier 1 genomic conditions. Monogenic variants Monogenic variants […]

Genetic risk for Alzheimer’s progression differs with sex

It is well documented that the genetic risk for Alzheimer’s has a sex bias. Sex bias in Alzheimer’s Carrying a […]