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Mitochondrial DNA genotype-phenotype interactions

A recent study has found that genetic variants in mitochondrial DNA could increase the risk of developing several common diseases, […]

Phenotype prediction accuracy limited by negative selection

Using population genetic models, researchers show that negative selection on complex traits limits phenotype prediction accuracy between populations. Phenotype prediction […]

Mitochondrial stress: a phenotype of spaceflight

Spaceflight is known to impact human physiology, but the distinct molecular aetiologies are unknown. In a recent study, published in […]

Pheno-RNA: a method to associate genes with phenotypes

In a recent article, published in PNAS, researchers have described a new method – Pheno-RNA – to identify candidate genes […]

Human brain-derived proteome data helps elucidate a genetic causal pathway for neurological phenotypes

A team of researchers have analysed human proteome data from brain tissue to study whether targeted proteins predictively mediated the […]

CRISPR screen unveils the stickiness of T cells

A new study has pinpointed a previously unknown molecular inhibitor of T cell adhesion. The study, published in Science Signalling, […]

Genomics week in brief: Week ending 23rd July

Check out the latest Genomics Week in Brief – full of intriguing news and research from the genomics space! Top […]

A Spotlight On: Variants of uncertain significance – Kimberly Gilmour

Kimberly Gilmour is Director of Laboratory Medicine at Great Ormond Street Hospital for Children. She utilises next generation sequencing and […]

Cancer cell competition sheds light on drug resistant lung cancers

A new study has demonstrated competitive exclusion in gefitinib resistant and sensitive ancestor lung cancers, providing a better understanding of […]

IL-33 secreting senescent cells offer new target for obesity-based liver cancer

New research has discovered how senescent cells and their secretion of IL-33 can encourage immunosuppression and tumour expansion in obesity-linked […]