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Search results for: Down Syndrome

Why do people with Down syndrome develop Alzheimer’s?

For the first time, researchers carried out single-cell transcriptomic analysis and long-read sequencing in Down syndrome brains to better understand […]

Down syndrome: New genetic approaches

A recent review, published in Cell, has examined the lessons learned from model systems and has explored emerging methods for […]

Rebalancing immune hyperactivity in Down’s syndrome

Written by Charlotte Harrison, Science Writer  People with Down’s syndrome have chronic hyperactivation of interferon signalling, meaning they are at […]

Uncovering the mechanisms behind autoimmunity in Down’s syndrome

A study, recently published in Nature, has revealed the mechanisms underpinning autoimmune susceptibility in individuals with Down’s syndrome. The researchers […]

Transcriptional buffering safeguards cells in Rett syndrome

Written by Charlotte Harrison, Science Writer. A study published in Nature Communications offers new insight into the mechanisms involved in the […]

Down the Rabbit Hole: Genomics of tree health and adaptation – Richard Buggs, Evolutionary Biologist

Richard Buggs is a Professor of Evolutionary Genomics at Queen Mary, University of London (QMUL) and a Senior Research Leader […]

Patient Perspectives: Vaila Morrison – Architect, Mother and Rare Disease Advocate (KAT6A syndrome)

Vaila Morrison is an architect focused on sustainable and inclusive design as well as a mother to a child with […]

Modified guide RNAs boost CRISPR-Cas13 transcript knockdown

Researchers at New York University and the New York Genome Center have developed chemically modified guide RNAs that enhance CRISPR-Cas13 […]

Down the Rabbit Hole: Genetics and Obesity – Giles Yeo

Giles Yeo is a Principal Research Associate at MRC Metabolic Diseases Unit and the Scientific Director of the Genomics/Transcriptomics Core […]

A novel pathway in the pathology of Rett syndrome

Researchers have revealed how dysregulation of the MECP2/miR-199a axis may contribute to the molecular pathology of Rett syndrome. Rett syndrome […]